[quote=111931]In short…no.
.exe’s are windows executable files. Retropie is run off of a linux base. It cannot run .exe’s. You can look online and see if there is a linux version of it (sadly, that’s not super common though) and if there is you can start a thread here and we (Buzz and Herb mainly) can help you get it running if it is possible for the pi.
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What about DRM free Linux games like those found in the humble bundles? Like VVVVVV or the binding of Issac. Or do they need to be specifically made for ARM processors?